A solutions architect is designing a company’s disaster recovery (DR) architecture. The company has a MySQL database on an Amazon EC2 instance in a private subnet with scheduled backups. The DR design must include multiple AWS Regions and require the LEAST operational overhead. Which solution meets these requirements?

Migrating the MySQL database to an Amazon Aurora global database with the primary DB cluster in the primary Region and the secondary DB cluster in the DR Region is the most suitable solution. Aurora Global Database is specifically designed for disaster recovery across regions, offering low RPO (Recovery Point Objective) and RTO (Recovery Time Objective) with minimal operational overhead because it handles replication automatically. Migrating to multiple EC2 instances with a standby in the DR Region and manual replication increases operational overhead significantly. Using Amazon RDS with Multi-AZ is good for high availability within a single region, but it doesn't provide cross-region disaster recovery. While S3 Cross-Region Replication for backups can be part of a DR strategy, restoring from backups is a slower process with higher RTO and RPO compared to an Aurora Global Database.