At which point during the campaign management timeline should an advertiser use manual optimization levers?

Advertisers should use manual optimization levers after reviewing campaign insights. This allows them to make data-driven decisions based on performance trends, identifying what's working and what isn't. Optimizing immediately after setup is premature, as there isn't enough data to inform effective changes. Optimizing before pulling downloadable reports is also inefficient; reports are a key source of the insights needed to guide optimization efforts. The correct sequence is to gather data, analyze insights, and then apply targeted manual optimizations to improve campaign performance.