Design global URL-path based load balancing with end-to-end in-transit encryption per Google best practices. What should you do?

An HTTPS load balancer with URL Maps is the correct choice. HTTPS load balancing is a global service that inherently supports URL-path based routing through URL Maps. It also provides end-to-end encryption. The load balancer terminates SSL/TLS from the client and can re-encrypt traffic to backends using SSL/TLS, fulfilling the in-transit encryption requirement. Cross-region load balancers are not a specific Google Cloud load balancer type; rather, global load balancers (like HTTPS) can span regions. SSL Proxy load balancing is for non-HTTP(S) traffic requiring SSL/TLS termination and doesn't inherently support URL Maps for path-based routing. A global forwarding rule is a component of a global load balancer, not a complete solution on its own.