You need to set up a highly available and fault-tolerant architecture for a mission-critical application. You decide to use Compute Engine instances in multiple regions. How would you manage the traffic routing for optimal latency?

*Explanation:* To manage traffic routing for optimal latency in a highly available and fault-tolerant architecture with Compute Engine instances in multiple regions, the best choice is to **Use Cloud Load Balancer with HTTP(S) protocol and set up Global routing**. Cloud Load Balancer will distribute incoming traffic across multiple regions, optimizing for latency. Other options like Cloud DNS Geolocation routing (doesn't manage traffic for Compute Engine instances), VPC Peering and Static IP routing (won't automatically manage for optimal latency), Cloud Endpoints with Global API Gateway (not designed for this use-case), and a combination of Cloud NAT and Regional Load Balancer (won't provide global routing) are not as suitable for this specific requirement.